Significant Morphine Overdose Due to Transcription Error and Failure to Question High Dose
Summary
The deficiency involves the facility’s failure to ensure a resident was free from significant medication errors when an opioid analgesic order was inaccurately transcribed and an abnormally large dose was administered without verification. Hospice orders for the resident dated 3/5/26 specified Morphine Sulfate (concentrate) oral solution 100 mg per 5 mL, with a dose of 0.25 mL by mouth every two hours as needed for moderate pain or air hunger. However, the physician order sheet for March 2026 documented the same medication and concentration but with a dose of 30 mL by mouth every two hours as needed, which represented a 100-fold increase over the prescribed dose. This incorrect dose was also reflected on the resident’s Medication Administration Record (MAR), indicating that the transcription error carried through to the record used for medication administration. On 3/10/26, the RN responsible for the resident’s care administered approximately 25–30 mL of Morphine Sulfate orally, consistent with the incorrectly transcribed order rather than the original hospice order of 0.25 mL. The RN later stated that the order had been transcribed incorrectly into the physician orders and MAR and acknowledged that she should have verified the order and questioned the unusually large dose. She also confirmed that she failed to document the administered dose on the corresponding narcotic count sheet, contrary to facility policy requiring controlled substances to be recorded on the designated usage form and controlled drug record. The facility’s policies required nurses to follow the six rights of medication administration, compare the medication source with the MAR, and refer to drug reference material if unfamiliar with a medication, but these safeguards were not effectively applied in this instance. Following the administration of the overdose, the resident initially went about her normal routine but later became very difficult to arouse. When a hospice CNA arrived around midday to provide care, the resident was sleeping, responded in a very quiet whisper that she was in pain, and was difficult to awaken. The CNA reported the situation to the RN, who then realized she had given the wrong dose earlier that morning and had no additional morphine available. The CNA and hospice staff observed that the resident was very drowsy, hard to wake, and had shallow, slow respirations that required placing a hand on the resident’s chest to count breaths. A hospice RN later documented a respiratory rate of eight breaths per minute, and a hospice LPN that evening noted periods of apnea, a respiratory rate of ten, eye-rolling, and brief unresponsiveness, leading to the decision to transfer the resident to the emergency room for evaluation of the morphine overdose. The resident later reported that the dose she received that morning was much larger than normal, that she usually received the medication in a small dropper under her tongue rather than in a medicine cup, and that she had no memory of events between breakfast and being told she was going to the hospital, describing the day as a blank and stating she was glad to still be alive. The facility’s pharmacist and hospice medical doctor confirmed that the dose administered, approximately 500 mg of oral morphine, was a high dose and that an overdose of concentrated oral morphine could result in shallow breathing, decreased respirations, impaired cognition, and potentially death. The facility’s medication error report documented that there was a transcription error with the morphine order, that the dose was supposed to be 0.25 mL orally every two hours as needed but was transcribed as 30 mL orally every two hours as needed, and that the administering nurse did not question the order and administered 30 mL of morphine sulfate. The report further documented that the error could have endangered the resident and had a high potential for adverse reactions up to and including death. The DON confirmed that the RN did not verify the inaccurate dose or question the abnormally large dose, which led to the administration of approximately 25 mL (500 mg) of oral morphine sulfate and resulted in the morphine overdose for the resident.
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